Clinical Research Directory

Inclusion Criteria: 1. Confirmed acute ischemic stroke by cranial CT or MRI. 2. Age 18 years or older. 3. Glasgow Coma Scale score of 6 to 12. 4. No artificial airway and no requirement for invasive mechanical ventilation at enrollment. 5. Written informed consent provided by the participant or legally authorized representative. Exclusion Criteria: 1. Existing artificial airway or invasive mechanical ventilation at ICU admission or screening. 2. Pre-existing pulmonary infection at enrollment, or definite extra-pulmonary organ or tissue infection during the study period. 3. Hemorrhagic blood disorder, clinically significant coagulopathy, or bleeding risk precluding laryngoscopy. 4. Oral or maxillofacial deformity impeding laryngoscope insertion. 5. Cervical spine fracture, atlantoaxial instability, or other condition restricting neck extension or movement. 6. Confirmed or suspected pregnancy. 7. Irreversible critical illness with anticipated survival less than 28 days. 8. Uncontrolled hypertension or recurrent malignant arrhythmias. 9. Other conditions judged by investigators to make participation unsuitable.