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Contrast-enhanced CBCT With C-arm HyperSight Technology
Sponsor: University Health Network, Toronto
Summary
This is a single-arm prospective, feasibility study evaluating the intravenous contrast-enhanced cone beam computed tomography (IV CBCT) for image guidance during radiotherapy. Patients treated with SFRT will receive IV-contrast enhanced CT and fMRI before treatment for simulation purposes. Additionally, patients will receive mpMRI just before and IV-contrast enhanced CBCT during their second and last fraction of RT, in addition to the standard of care CBCT that is acquired for daily image-guided patient positioning. Patients will undergo both IV-contrast enhanced CBCT and treatment on the TrueBeam with HyperSight imaging capability. We hypothesize IV contrast enhanced CBCT is feasible, well-tolerated by patients and improves the visibility of the target.
Official title: Contrast-enhanced CBCT With C-arm HyperSight Technology: A Feasibility Study
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
20
Start Date
2026-07-01
Completion Date
2027-07-01
Last Updated
2026-06-15
Healthy Volunteers
No
Conditions
Interventions
Intravenous contrast-enhanced cone beam computed tomography
Two half-arc IV-contrast enhanced CBCT scans and mpMRI seuqences in addition to their routine standard of care CBCT that is done as part of image-guided radiotherapy. These scans will be done during the second and last fraction of treatment.
Locations (1)
Princess Margaret Cancer Center
Toronto, Ontario, Canada