Clinical Research Directory

Inclusion Criteria: * Patients with established diagnosis of Crohn's Disease * Patients with active inflammation, defined as HBI score ≥ 5 and either CRP\>5 or stool calprotectin\>250 mcg/gr. * Patients starting advanced treatment as part of routine medical care (Anti TNFs, vedolizumab, Ustekinumab, IL-23 inhibitors, Jak inhibitors or S1P inhibitors). Exclusion Criteria: * Inability to give informed consent and complete the study protocol. * Pregnant or lactating women * Inability or reluctance to follow through with the study protocol, including (but not exclusive) to: questionnaires, wearing the watch while sleeping. * Patients diagnosed with UC or indeterminate IBD. * Other sleep disorders Obstructive sleep apnea overactive bladder insomnia shift work disorder restless leg syndrome Periodic limb movement of sleep Narcolepsy * Use of sleep medication - such as benzodiazepines or cannabis. * Recent abdominal surgery - previous 4 weeks. * Severe systemic disease - CVD, Kidney, liver - as jugged by physician's discretion. * Patients with ileostomy or short bowl syndrome.