Clinical Research Directory

Inclusion Criteria: For the group of patients with MVCR: * Patients aged between 18 and 80 years at the time of inclusion * Diagnosis confirmed by the detection of a pathogenic mutation in the NOTCH3 gene characteristic of CADASIL, or in another gene responsible for other forms of monogenic cSVD (such as the COL4A1, COL4A2 and HTRA1 genes) or a confirmed diagnosis of MOYA-MOYA (arteriography and/or genetic testing) or cavernoma, cerebral venous thrombosis or a cerebral vascular malformation, including cavernomas * Covered by social security or an equivalent scheme * Written consent. * Patient included in the MVCR cohort For control group * Subject aged between 18 and 80 at the time of inclusion. * Written consent. * Blood pressure \< 140/90 mmHg without treatment or \< 130/80 mmHg if treated and stable for ≥3 months * Covered by social security or a similar scheme * Strictly normal neurological examination (NIHSS=0; no focal deficit) * Normal cognitive examination: MMSE ≥ 26 Exclusion criteria : Common exclusion criteria for patients and control subjects: * A person referred to in Articles L. 1121-5 to L. 1121-8 and L. 1122-12 of the Public Health Code, defined as: * Pregnant women, women in labour or breastfeeding women * Persons deprived of their liberty by judicial or administrative decision * Persons hospitalised without consent and not subject to a legal protection measure, and persons admitted to a health or social care facility for purposes other than research * Minors * Adults subject to a legal protection measure (guardianship, curatorship or judicial protection), adults unable to give consent and not subject to a legal protection measure * Individuals subject to a withdrawal period for another research study * Patients participating in another interventional research study * Acute or chronic infectious disease Specific exclusion criteria for control subjects * Any identified extra- or intracranial vascular pathology requiring specific management * Known cardiovascular disease (coronary artery disease, arterial disease, atrial fibrillation, heart failure) * Neurological history: stroke, TIA, intracranial haemorrhage, meningitis/encephalitis, head injury with loss of consciousness \>30 mins, * Multiple sclerosis, neurodegenerative disease, active epilepsy, * Current or former smoking (more than 10 pack-years) * Diabetes * Antithrombotic or lipid-lowering treatment