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Genetic, Microbiological and Behavioral Factors in Obesity
Sponsor: Jan Kochanowski University
Summary
This study will assess the impact of genetic markers, microbiological (microbiome) and behavioral factors on tolerance, adherence and effectiveness of dual GLP1/GIP RA in the treatment of obesity. 200 consecutive patients who meet all inclusion and none of the exclusion criteria will be enrolled.
Official title: OPTIMIZE GEN - Outcomes of Persistence and Treatment With tIrzepatide deterMined by Genetic, mIcrobiological & bEhavioral Factors in obEsity
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
OBSERVATIONAL
Enrollment
200
Start Date
2026-05-23
Completion Date
2028-05
Last Updated
2026-09-23
Healthy Volunteers
No
Conditions
Interventions
genetic polymorphism
GLP1 RA and GIP R polymorphisms will be assesed from venous blood samples
gut microbiome
stool samples and oral cavity swabs for gut microbiome will be collected to assess V3 and V4 of gene 16s rRNA
Locations (2)
Waga Zmiany
Krakow, Poland
Luxmed sp zoo
Warsaw, Poland