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ACTIVE NOT RECRUITING
NCT07651085

Biomarkers in Alzheimer's and Parkinson's Diseases for IA

Sponsor: IRCCS San Raffaele Roma

View on ClinicalTrials.gov

Summary

Investigate whether endogenous and exogenous risk factors, the presence of pathological amyloid aggregates and alpha-synuclein in the CSF, brain connectivity, and some clinical and biological indices such as vigilance, general motility, the sleep-wake cycle, genomic instability and possible DNA damage may correlate with (or predict) the clinical condition of mild cognitive impairment (MCI) and dementia in patients with Alzheimer's disease (AD) and Parkinson's disease (PD).

Official title: Effects of Endogenous and Exogenous Risk Factors in Patients With Alzheimer's and Parkinson's Diseases Using Clinical Indexes and Endophenotypes (Biomarkers) as Inputs to Artificial Intelligence

Key Details

Gender

All

Age Range

60 Years - Any

Study Type

OBSERVATIONAL

Enrollment

65

Start Date

2024-02-08

Completion Date

2027-07-20

Last Updated

2026-06-16

Healthy Volunteers

Not specified

Interventions

DIAGNOSTIC_TEST

Neuropsycological assesment

Administration of Cognitive and Behavioral Tests

RADIATION

cerebral MRI

Brain connectivity assessed through MRI biomarkers

OTHER

EEG

Brain connectivity assessed through EEG biomarkers

BIOLOGICAL

Venous blood sample of 20ml

Venous blood sample of 20ml

BIOLOGICAL

Sample collection of exfoliated buccal mucosa

Sample collection of exfoliated buccal mucosa

DEVICE

Telemonitoring at home for 1 week

Patients are trained in the correct use of home telemonitoring devices. The staff will guide the patient in the use of the devices, training him in the autonomous management of the instruments. The devices delivered to each patient will be the Samsung Galaxy4 smartwatch, and a Samsung tablet with the serious games SMARTME\&YOU video game application installed.

Locations (1)

IRCCS San Raffaele Roma

Rome, Italy, Italy