Clinical Research Directory
Browse clinical research sites, groups, and studies.
Biomarkers in Alzheimer's and Parkinson's Diseases for IA
Sponsor: IRCCS San Raffaele Roma
Summary
Investigate whether endogenous and exogenous risk factors, the presence of pathological amyloid aggregates and alpha-synuclein in the CSF, brain connectivity, and some clinical and biological indices such as vigilance, general motility, the sleep-wake cycle, genomic instability and possible DNA damage may correlate with (or predict) the clinical condition of mild cognitive impairment (MCI) and dementia in patients with Alzheimer's disease (AD) and Parkinson's disease (PD).
Official title: Effects of Endogenous and Exogenous Risk Factors in Patients With Alzheimer's and Parkinson's Diseases Using Clinical Indexes and Endophenotypes (Biomarkers) as Inputs to Artificial Intelligence
Key Details
Gender
All
Age Range
60 Years - Any
Study Type
OBSERVATIONAL
Enrollment
65
Start Date
2024-02-08
Completion Date
2027-07-20
Last Updated
2026-06-16
Healthy Volunteers
Not specified
Interventions
Neuropsycological assesment
Administration of Cognitive and Behavioral Tests
cerebral MRI
Brain connectivity assessed through MRI biomarkers
EEG
Brain connectivity assessed through EEG biomarkers
Venous blood sample of 20ml
Venous blood sample of 20ml
Sample collection of exfoliated buccal mucosa
Sample collection of exfoliated buccal mucosa
Telemonitoring at home for 1 week
Patients are trained in the correct use of home telemonitoring devices. The staff will guide the patient in the use of the devices, training him in the autonomous management of the instruments. The devices delivered to each patient will be the Samsung Galaxy4 smartwatch, and a Samsung tablet with the serious games SMARTME\&YOU video game application installed.
Locations (1)
IRCCS San Raffaele Roma
Rome, Italy, Italy