Clinical Research Directory

Inclusion Criteria: 1. Age 18-75 years 2. Confirmed diagnosis of R/R AML 3. Adequate organ function: TBIL ≤2×ULN; ALT/AST ≤2.5×ULN; Cr ≤ULN or Ccr ≥50 mL/min 4. ECOG performance status ≤2 5. Life expectancy ≥4 months 6. No severe allergic history 7. Not participating in other interventional trials during study 8. Signed informed consent - Exclusion Criteria: 1. Hypersensitivity to any study drug 2. Dysphagia or uncontrolled gastrointestinal disease impairing oral intake 3. Acute promyelocytic leukemia (APL) 4. Prior treatment with EZH1/2 inhibitors 5. Allogeneic hematopoietic stem cell transplantation within 6 months 6. Participation in another interventional trial within 4 weeks 7. Smoking and excessive drinking have affected the evaluation of the test results; 8. Undergone major organ surgery within the previous 6 weeks and whose recovery was not complete 9. Severe chronic respiratory disease requiring continuous oxygen 10. Clinically significant cardiac, renal, hepatic, neurologic, or endocrine disease; Child-Pugh B/C cirrhosis 11. Active uncontrolled infection including HBV, HCV, HIV, syphilis 12. Pregnant or breastfeeding women; women planning pregnancy during study 13. The patients deemed unsuitable by the researchers to participate in this study. -