Bone Defects Reconstruction After Dentigerous Cyst Enucleation With Autogenous Demineralized Dentin Matrix- ADDM and Platelet Rich Fibrin- PRF.

ACTIVE NOT RECRUITING

NCT07652216

NA

Sponsor: Jagiellonian University

Summary

This prospective clinical study evaluates bone healing following dentigerous cyst enucleation associated with impacted mandibular third molar extraction. The study compares spontaneous blood clot healing, advanced platelet-rich fibrin (A-PRF), and A-PRF combined with allogenic dentin-derived matrix (ADDM). Bone healing is assessed as the primary outcome, while postoperative pain intensity assessed using the Numerical Rating Scale (NRS) with graphical representation represents a secondary outcome. The study aims to determine whether the use of A-PRF or A-PRF combined with ADDM improves postoperative healing outcomes compared with spontaneous blood clot healing.

Key Details

Gender

All

Age Range

Any - Any

Study Type

INTERVENTIONAL

Enrollment

35

Start Date

2024-04-04

Completion Date

2027-04-01

Last Updated

2026-06-17

Healthy Volunteers

No

Conditions

Impact Molar Mandible Cyst Bone Regeneration Platelet Rich Fibrin Dentigerous Cyst Dentin Matrix Autogenous Dentin Graft Demineralized Dentin Matrix Impacted Lower Third Molar Impacted Mandibular Third Molar

Interventions

PROCEDURE

Impacted third molar extraction with associated dentigerous cyst enucleation- blood clot healing

Surgical extraction of impacted mandibular third molars combines with enucleation of associated dentigerous cysts performed under standarized clinical conditions.

PROCEDURE

Impacted third molar extraction with associated dentigerous cyst enucleation- regeneration with Advanced Platelet Rich Fibrin

Application of autologous advanced platelet rich fibrin (A-PRF) into the postoperative defect following enucleation of mandibular dentigerous cyst and extraction of associated impacted third molar to support regenerative healing.

PROCEDURE

Impacted third molar extraction with associated dentigerous cyst enucleation- regeneration with Advanced Platelet Rich Fibrin and Autogenous Demineralized Dentin Matrix

Application of autologous advanced platelet rich fibrin (A-PRF) and antogenous demineralized dentin matrix (ADDM) into the postoperative defect following enucleation of mandibular dentigerous cyst and extraction of associated impacted third molar to support regenerative healing.

Locations (1)

Department of Oral Surgery, Institute of Dentistry, Jagiellonian University Medical College

Krakow, Malopolska, Poland

Clinical Research Directory