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Bone Defects Reconstruction After Dentigerous Cyst Enucleation With Autogenous Demineralized Dentin Matrix- ADDM and Advanced Platelet-Rich Fibrin- A-PRF.
Sponsor: Jagiellonian University
Summary
This prospective clinical study evaluates bone healing following dentigerous cyst enucleation associated with impacted mandibular third molar extraction. The study compares spontaneous blood clot healing, Advanced Platelet-Rich fibrin (A-PRF), and A-PRF combined with Autogenous Dentin Demineralized Matrix (ADDM). Bone healing is assessed as the primary outcome, while postoperative pain intensity assessed using the Numerical Rating Scale (NRS) with graphical representation represents a secondary outcome. The study aims to determine whether the use of A-PRF or A-PRF combined with ADDM improves postoperative healing outcomes compared with spontaneous blood clot healing.
Key Details
Gender
All
Age Range
Any - Any
Study Type
INTERVENTIONAL
Enrollment
35
Start Date
2024-04-04
Completion Date
2027-04-01
Last Updated
2026-06-23
Healthy Volunteers
No
Conditions
Interventions
Impacted third molar extraction
Surgical extraction of impacted mandibular third molar performed under standarized clinical conditions
Advanced Platelet-Rich Fibrin (A-PRF)
Application of autologous Advanced Platelet-Rich Fibrin (A-PRF) into the postoperative defect to support regenerative healing
Mandibular dentigerous cyst enucleation
Complete surgical enucleation of the mandibular dentigerous cyst associated with the impacted mandibular third molar
Autogenous Demineralized Dentin Matrix (ADDM)
Application of Autogenous Demineralized Dentin Matrix prepared from extracted tooth material to support bone regeneration
Locations (1)
Department of Oral Surgery, Institute of Dentistry, Jagiellonian University Medical College
Krakow, Malopolska, Poland