Clinical Research Directory

Inclusion Criteria: 1. Age: 50-79 years, regardless of sex. 2. Blood Pressure: Systolic blood pressure (SBP) 130 ≤ SBP \< 140 mmHg and/or diastolic blood pressure (DBP) 85 ≤ DBP \< 90 mmHg. 3. Presence of at least one cardiovascular risk factor. 4. Capacity to provide informed consent. Exclusion Criteria: 1. Diabetes mellitus (FPG ≥ 7.0 mmol/L and/or OGTT 2h PG ≥ 11.1 mmol/L). 2. Hypertension (SBP ≥ 140 mmHg and/or DBP ≥ 90 mmHg) or current use of antihypertensive medication. 3. Participation in another clinical trial within 3 months prior to enrollment or concurrently with this study. 4. Significant renal impairment (serum creatinine ≥ 2.5 mg/dL). 5. Significant hepatic dysfunction (ALT \> 2 × upper limit of normal \[ULN\]). 6. Serum potassium \< 3.5 mmol/L or \> 5.6 mmol/L. 7. Known hypersensitivity to the investigational drugs used in this study. 8. History of stroke or myocardial infarction within 3 months prior to study entry. 9. Undergoing or scheduled for percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) within 3 months prior to study start. 10. Other serious medical conditions (e.g., malignant tumors). 11. Pregnant women or women of childbearing potential who are not using effective contraception or likely to become pregnant. 12. Patients who are bedridden or unable to attend clinic visits. 13. Any other condition requiring antihypertensive medication. 14. Any indication or contraindication for the investigational drug or other antihypertensive agents. 15. Subjects deemed unsuitable for inclusion by the investigator.