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Toxin Exposure and Immune Dysregulation in Non-Hodgkin Lymphoma
Sponsor: Henry M. Jackson Foundation for the Advancement of Military Medicine
Summary
The goal of this observational cohort study is to learn how toxin and occupational exposures, germline genetic variation, and immune dysregulation relate to B-cell non-Hodgkin lymphoma among active-duty service members and other Military Health System beneficiaries. The main questions are whether specific exposures and germline variants are associated with B-cell NHL subtype, immune dysfunction, and clinical outcomes. Participants will complete exposure and medical-history surveys, provide biospecimens for immune and genomic testing, and may be followed annually for up to 3 years.
Official title: Toxin Exposure and Immune Dysregulation in Non-Hodgkin Lymphoma Across the Military Healthcare System
Key Details
Gender
All
Age Range
4 Years - Any
Study Type
OBSERVATIONAL
Enrollment
300
Start Date
2025-05-01
Completion Date
2028-05-01
Last Updated
2026-06-17
Healthy Volunteers
No
Locations (3)
Uniformed Services University of the Health Sciences
Bethesda, Maryland, United States
Walter Reed National Military Medical Center
Bethesda, Maryland, United States
Naval Medical Center Portsmouth
Portsmouth, Virginia, United States