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Effect of Enamel Cleaning on a Remineralizing Paste for Hypomineralizated Lesions
Sponsor: Universidade Ceuma
Summary
Molar-incisor hypomineralization (MIH) is a qualitative defect of dental enamel, in which low mineral content and high protein content compromise the effectiveness of remineralizing treatments. Various agents have been used to remove proteins from hypomineralized enamel, such as sodium hypochlorite (NaOCl). Sodium hypochlorite is an antimicrobial irrigant capable of dissolving tissues. CPP-ACPF is used as a remineralizing agent for MIH lesions, it is capable of stabilizing calcium, phosphate, and fluoride ions on the tooth surface, maintaining them in an amorphous form. Therefore, the objective of this study is to evaluate the clinical performance of amorphous calcium fluoride casein phosphate phosphopeptide (CPP-ACPF) dental mousse on deproteinized hypomineralized enamel.
Official title: The Effect Of Deproteinization On The Performance Of CPP-ACPF On Hypomineralized Enamel: A Clinical Evaluation
Key Details
Gender
All
Age Range
7 Years - 9 Years
Study Type
INTERVENTIONAL
Enrollment
54
Start Date
2026-08
Completion Date
2028-04
Last Updated
2026-06-17
Healthy Volunteers
Yes
Conditions
Interventions
Sodium hypochlorite 5.25%
Sodium hypochlorite is a proteolytic substance that interferes with the cellular metabolism of proteins.
CPP-ACPF
Casein is a milk-derived protein that, during enzymatic digestion in the mouth, is converted into a casein phosphopeptide (CPP) molecule. CPP is capable of stabilizing calcium, phosphate, and fluoride ions on the tooth surface, keeping them in an amorphous form. Thus, CPP-ACPF functions as a reservoir of calcium phosphate.
Locations (1)
Universidade Ceuma
São Luís, Maranhão, Brazil