Clinical Research Directory

Inclusion Criteria: * Signed informed consent prior to participation in the study. * Age ≥ 18 years. * Histologically or cytologically confirmed unresectable stage III non-small cell lung cancer. * Completion of concurrent platinum-based chemoradiotherapy * Eligibility for adjuvant durvalumab per standard of care. * At least one tumor lesion or involved lymph node accessible by bronchoscopy or endoscopic/endobronchial ultrasound, suitable for biopsy/fine-needle aspiration (FNA) and fluorescence measurement. * Eastern Cooperative Oncology Group (ECOG) performance status 0-2. * Patient is considered fit to undergo a research bronchoscopy (with or without addition of endobronchial ultrasound; including propofol sedation or general anesthesia if either is indicated). Exclusion Criteria: * Known history of infusion reactions to durvalumab, other anti-PD-L1 antibodies, or other monoclonal antibodies, according to the patient's medical history. * Contraindication for bronchoscopy or endoscopic/endobronchial ultrasound (if applicable), including severe uncorrectable coagulopathy, pre-existing severe respiratory insufficiency, or any other clinical reason as judged by the investigator. * Medical or psychiatric conditions compromising the patient's ability to provide informed consent, according to the treating physician. * Pregnancy or breastfeeding. A negative pregnancy test must be available for women of childbearing potential on the day of tracer administration. * Use of an investigational medicinal product within 30 days prior to tracer administration.