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Hemodynamic Effects of Norepinephrine Reduction on Critical Closing Pressure in Distributive Shock
Sponsor: Peking Union Medical College Hospital
Summary
This study prospectively observes changes in critical closing pressure (Pcc) and derived hemodynamic parameters in mechanically ventilated distributive shock patients when clinically indicated norepinephrine dose reduction is performed by the attending physician. Pcc is measured before and 30 minutes after dose reduction using a stepwise inspiratory hold maneuver via PiCCO monitoring.
Official title: Changes in Critical Closing Pressure and Derived Hemodynamic Parameters Following Norepinephrine Dose Reduction in Distributive Shock Patients: a Prospective Observational Study
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
30
Start Date
2025-09-01
Completion Date
2027-09-01
Last Updated
2026-06-17
Healthy Volunteers
No
Interventions
Not applicable- observational study
Observation of hemodynamic parameters before and after clinically indicated norepinephrine dose reduction. No investigator-initiated intervention was performed.
Locations (1)
Peking Union Medical College Hospital
Beijing, Beijing Municipality, China