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Near-Infrared Spectroscopy, Acute Taurine Supplementation, and Isolated Muscular Endurance and Fatigue Resistance in Young Healthy Adults
Sponsor: Louisiana State University and A&M College
Summary
The goal of this clinical trial is to determine the association between near-infrared spectroscopy (NIRS)-derived mitochondrial oxidative phosphorylation (OXPHOS) capacity of the vastus lateralis muscles, and both local muscular endurance capacity and local muscular fatiguability of the thigh muscles in young adults. Additionally, this trial aims to determine the effect of acute taurine supplementation on local muscular endurance capacity and local muscular fatiguability when compared to a placebo condition. The main questions it aims to answer are: 1. Will there be a positive correlation between NIRS rate constant (a marker of mitochondrial function) and local muscular endurance capacity, along with a negative correlation between NIRS rate constant and local muscular fatiguability? 2. Will acute taurine supplementation lead to improvements in local muscular endurance capacity and local muscular fatiguability when compared to a placebo condition? Participants will: 1. Complete a NIRS assessment to non-invasively assess the mitochondrial capacity of both vastus lateralis muscles 2. Complete two acute supplementation assessment visits (separated by 7-10 days) which involve small blood collections before and after taurine or placebo supplementation 3. Perform a single-leg extension time-to-exhaustion test to measure local muscular endurance capacity on one leg, along with a repeated maximal voluntary isometric contraction fatigue index test to measure local muscular fatiguability on the opposite leg, during each acute supplementation assessment visit.
Official title: Near-Infrared Spectroscopy-Derived Mitochondrial Oxidative Phosphorylation Capacity, Local Muscular Fatigue Resistance, and the Effects of Acute Taurine Supplementation
Key Details
Gender
All
Age Range
18 Years - 40 Years
Study Type
INTERVENTIONAL
Enrollment
34
Start Date
2026-06-22
Completion Date
2027-01-15
Last Updated
2026-06-17
Healthy Volunteers
Yes
Conditions
Interventions
Acute Taurine Supplementation
Participants will ingest six taurine capsules (6 grams of taurine) following a baseline blood collection to determine baseline plasma taurine levels. 60 minutes following ingestion, there will be an additional blood collection to determine post-supplementation plasma taurine levels. Participants will then perform exercise assessments. The order of taurine supplementation relative to placebo supplementation will be randomized in a double-blind crossover with 7-10 days separating each condition.
Acute Placebo Supplementation
Participants will ingest six placebo capsules (1.2 grams of microcrystalline cellulose) following a baseline blood collection to determine baseline plasma taurine levels. 60 minutes following ingestion, there will be an additional blood collection to determine post-supplementation plasma taurine levels. Participants will then perform exercise assessments. The order of placebo supplementation relative to taurine supplementation will be randomized in a double-blind crossover with 7-10 days separating each condition.