Clinical Research Directory

Inclusion Criteria: * Male or female, aged 18 to 70 years. * Definitive diagnosis of chronic cholecystitis (with or without gallstones), referencing the Chinese Medical Association guidelines or relevant clinical diagnostic criteria. * Presence of clinical symptoms including recurrent right upper quadrant discomfort or dull pain, or accompanying dyspeptic symptoms (such as abdominal bloating, belching, or nausea), with symptoms persisting or recurring for more than 3 months prior to enrollment. * Imaging support: Abdominal ultrasound within 3 months prior to enrollment indicating gallbladder wall thickening (typically \> 3 mm) or wall roughness. * Voluntary participation and signed written informed consent form. Exclusion Criteria: * Acute exacerbation of cholecystitis, purulent or gangrenous cholecystitis, or accompanying biliary obstruction or severe cholangitis requiring emergency surgical intervention. * History of cholecystectomy or other major gastrointestinal surgeries (e.g., gastric bypass, bowel resection). * Comorbidities of other severe primary diseases or malignancies, including: severe cardiovascular, renal, or neurological diseases; severe liver diseases (e.g., cirrhosis, severe viral hepatitis); and malignancies (e.g., gallbladder cancer, gastrointestinal tumors). * Pregnant or lactating women, or those planning to conceive during the study period. * Use of the following medications or preparations within 4 weeks prior to enrollment: continuous use of antibiotics, other probiotic or prebiotic preparations; currently taking choleretic or litholytic drugs that may significantly affect bile acid metabolism (e.g., ursodeoxycholic acid). * Known allergy to dairy products, yogurt, or any intervention ingredients, or having severe lactose intolerance. * Any other conditions that, in the opinion of the investigator, make the subject unsuitable for participation in this clinical study.