Clinical Research Directory

Inclusion Criteria group 1 (resection tissue surgery patients = healthy volunteers): 1. Voluntary written informed consent of the participant has been obtained prior to any screening procedures 2. At least 18 years of age at the time of signing the Informed Consent Form (ICF) 3. Undergoing surgery for colorectal cancer 4. No preoperative radiotherapy or chemotherapy Exclusion Criteria group 1 (resection tissue surgery patients = healthy volunteers): 1. Using anti-histaminics such as ebastine, cetirizine, desloratadine, … (non-exhautive list) at the moment of surgery 2. Inflammatory bowel disease (IBD) or diverticulitis 3. Diabetes or BMI ≥ 30 kg/m² 4. Subject is legally incapacitated Inclusion Criteria group 2 (rectal biopsies from IBS patients): 1. Voluntary written informed consent of the subject has been obtained prior to any screening procedures 2. At least 18 years of age at the time of signing the Informed Consent Form (ICF) and maximum age of 65 years of age at the time of signing the ICF 3. Diagnosed with IBS Exclusion Criteria group 2 (rectal biopsies from IBS patients): 1. Subject has internal/external hemorrhoids at the moment of biopsy sampling. 2. Using blood-thinners such as Acenocoumarol, Aspirine (acetylsalicylzuur), Apixaban (Eliquis), Clopidogrel (Plavix), Dabigatran (Pradaxa), Edoxaban (Lixiana), Rivaroxaban (Xarelto), warfarine (Marevan®) and Enoxaparine (Clexane), … (non-exhausative list). 3. Using anti-histaminics such as ebastine, cetirizine, desloratadine, … (non-exhausative list) at the moment of biopsy sampling. Anti-histaminics should be stopped 2 weeks prior to the biopsy sampling. 4. Subject is legally incapacitated