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HFCWO Vest Plus Mechanical Cough Assist Versus Cough Assist Alone on Respiratory Infections in ALS: a Pilot Trial
Sponsor: Hospital Universitario Virgen Macarena
Summary
This pilot randomised single-blind trial evaluated whether adding high-frequency chest wall oscillation (HFCWO) via chest vest (ComfortCough II) to mechanical cough assist improves respiratory outcomes and reduces respiratory infections and hospital admissions compared to mechanical cough assist alone in patients with amyotrophic lateral sclerosis (ALS) receiving non-invasive ventilation.
Official title: Effect of High-frequency Chest Wall Oscillation (HFCWO) Via Chest Vest Combined With Mechanical Cough Assist Versus Mechanical Cough Assist Alone on Respiratory Infections and Hospital Admissions in Patients With Amyotrophic Lateral Sclerosis Receiving Non-invasive Ventilation: a Randomised Single-blind Pilot Trial
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
14
Start Date
2021-04-15
Completion Date
2025-04-27
Last Updated
2026-06-18
Healthy Volunteers
No
Interventions
High-frequency chest wall oscillation (HFCWO) vest
Chest wall oscillation vest delivering high-frequency vibrations to mobilise secretions, used in addition to mechanical cough assist device during the 3-month intervention period.
Mechanical cough assist
Mechanical insufflation-exsufflation device used alone for airway secretion clearance during the 3-month intervention period.
Locations (1)
Hospital Universitario Virgen Macarena
Seville, Andalusia, Spain