Clinical Research Directory
Browse clinical research sites, groups, and studies.
Predictive Value of Tumor Microenvironment PET/CT for Response and Prognosis in Aggressive Lymphoma
Sponsor: Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Summary
This multicenter study aims to evaluate the predictive value of tumor microenvironment PET/CT imaging for treatment response and prognosis in patients with aggressive lymphoma. Eligible patients with histologically confirmed aggressive lymphoma will undergo FAPI PET/CT imaging, and selected patients who are candidates for immunotherapy will undergo Grazytracer PET/CT imaging. These imaging methods are intended to assess fibroblast activation protein expression and granzyme B activity in lymphoma lesions, reflecting cancer-associated fibroblasts and cytotoxic T-cell activity in the tumor microenvironment. The study will explore optimal imaging assessment criteria and develop clinical-pathological-imaging models to predict treatment response, prognosis, and the relationship between tumor heterogeneity and refractory or relapsed disease.
Official title: The Predictive Value of Tumor Microenvironment PET/CT Imaging for Treatment Response and Prognosis in Aggressive Lymphoma: A Multicenter Clinical Study
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
94
Start Date
2024-07-11
Completion Date
2026-12-31
Last Updated
2026-10-07
Healthy Volunteers
No
Conditions
Interventions
Al18F-NOTA-FAPI
Al18F-NOTA-FAPI was injected into the patients before the PET/CT scans
Al18F-NOTA-grazytracer/68Ga-grazytracer
Al18F-NOTA-grazytracer/68Ga-grazytracer was injected into the patients before the PET/CT scans
Locations (1)
National Cancer Center/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College
Beijing, Chao Yang, China