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Topical Calcipotriol Versus Photodynamic Therapy in the Treatment of Oral Leukoplakia
Sponsor: Alexandria University
Summary
The goal of this clinical trial is to learn if calcipotriol and photodynamic therapy are equally effective in treatment of leukoplakia or not. The main questions it aims to answer are: do lesions decrease or disappear when treated by calcipotriol or PDT? does the drug affect the salivary biomarkers Participants will: Take calcipotriol daily for 4 weeks or perform 4 PDT sessions over 4 weeks measure changes in salivary biomarkers be followed up for 3 months
Official title: Topical Calcipotriol Gel Versus Photodynamic Therapy in the Treatment of Oral Leukoplakia: Randomized Clinical Trial
Key Details
Gender
All
Age Range
25 Years - 55 Years
Study Type
INTERVENTIONAL
Enrollment
30
Start Date
2025-07-16
Completion Date
2026-09-10
Last Updated
2026-06-22
Healthy Volunteers
No
Conditions
Interventions
Calcipotriol 0.005% gel
using prepared calcipotriol in orabase twice daily for 4 weeks
ALA mediated PDT
applying photodynamic therapy using laser device on photosensitizer
Locations (1)
Faculty of Dentistry, Alexandria University
Alexandria, Egypt