Clinical Research Directory

Inclusion Criteria: 1. Patients with essential hypertension whose blood pressure measured in visit1 corresponds to the following conditions * mean sitSBP \< 180 mmHg and mean sitDBP \< 110 mmHg for patients receiving any BP-lowering drug within 1 month prior to Visit 1 * 140 mmHg ≤ mean sitSBP \< 180 mmHg and 60 mmHg ≤ mean sitDBP \< 110 mmHg for patients not receiving BP-lowering drugs within 1 month prior to Visit 1 2. Patients with essential hypertension who meet 140 mmHg ≤ mean sitSBP \< 180 mmHg and 60 mmHg ≤ mean sitDBP \< 110 mmHg at Visit 2 Exclusion Criteria: 1. Difference between arms greater than 20 mmHg for mean sitSBP or 10 mmHg for mean sitDBP at Visit 1 2. Patients who have taken more than three components of Blood pressure medication within 3 months prior to Visit 1 3. Orthostatic hypotension with symptoms within 3 months prior to visit 1 4. Secondary hypertensive patient or suspected to be 5. Clinically significant hematological finding 6. Severe heart disease or severe neurovascular disease 7. Moderate or malignant retinopathy 8. Uncontrolled diabetes mellitus(HbA1c \> 9%) or type I diabetes mellitus 9. Active gout or hyperuricemia (uric acid ≥ 9mg/dL) 10. Severe renal diseases (eGFR \< 30mL/min/1.73m2) 11. Severe or active hepatopathy (AST or ALT ≥ 3 times of normal range) 12. Hypokalemia or Hyperkalemia (K \< 3.5mmol/L or K ≥ 5.5mmol/L) 13. Hyponatremia or Hypernatremia (Na \< 135mmol/L or Na ≥ 155mmol/L) 14. Hypercalcemia (Ca \> 12.5mg/dL) 15. History of malignancy tumor 16. History of autoimmune disease 17. History of alcohol or drug abuse 18. Positive to pregnancy test, nursing mother, intention on pregnancy 19. Considered by investigator as not appropriate to participate in the clinical study with other reason