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Remifentanil vs Esmolol During Intubation for Cerebral Aneurysm Coil Embolization
Sponsor: Fatih Sultan Mehmet Training and Research Hospital
Summary
Endotracheal intubation may cause significant increases in blood pressure, heart rate, and intracranial pressure, particularly in patients undergoing cerebral aneurysm coil embolization. Remifentanil and esmolol are commonly used agents to attenuate these responses during anesthesia induction. This randomized controlled trial aims to compare the effects of remifentanil and esmolol administered before endotracheal intubation on optic nerve sheath diameter/eyeball transverse diameter ratio (ONSD/ETD), a noninvasive surrogate marker of intracranial pressure, as well as hemodynamic responses in patients undergoing elective cerebral aneurysm coil embolization. The findings may help identify the most effective strategy for minimizing intubation-related intracranial pressure changes and hemodynamic fluctuations in neurointerventional anesthesia practice.
Official title: Effects of Remifentanil Versus Esmolol on Optic Nerve Sheath Diameter/Eyeball Transverse Diameter Ratio During Endotracheal Intubation in Patients Undergoing Cerebral Aneurysm Coil Embolization: A Randomized Controlled Trial
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
84
Start Date
2026-06-22
Completion Date
2027-07-01
Last Updated
2026-06-22
Healthy Volunteers
No
Interventions
Remifentanil
Remifentanil 0.5-1 µg/kg IV administered over 90 seconds before endotracheal intubation.
Esmolol
Esmolol 0.5-1 mg/kg IV administered over 90 seconds before endotracheal intubation.
Locations (1)
Fatih Sultan Mehmet Training and Research Hospital
Istanbul, Istanbul, Turkey (Türkiye)