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Olfactory Dysfunction in Aging Adults
Sponsor: Medical University of South Carolina
Summary
This prospective longitudinal cohort study will enroll adults aged 50 years and older to characterize olfactory dysfunction in aging. Participants will undergo comprehensive olfactory testing, cognitive assessment, biomarker collection, and imaging to identify clinically relevant phenotypes based on anatomic site of dysfunction. The study will also evaluate the impact of olfactory dysfunction on quality of life and identify baseline factors associated with changes in olfactory function over time.
Key Details
Gender
All
Age Range
50 Years - Any
Study Type
OBSERVATIONAL
Enrollment
500
Start Date
2027-04-01
Completion Date
2032-04-30
Last Updated
2026-06-22
Healthy Volunteers
Yes
Conditions
Interventions
Clinical and Biomarker Assessments
Participants undergo olfactory testing (Sniffin' Sticks), cognitive assessment, nasal endoscopy, olfactory mucus collection, MRI imaging (subset), and patient-reported outcome measures to evaluate olfactory function, biomarkers, and health outcomes over time.
Locations (1)
MUSC
Charleston, South Carolina, United States