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A Clinical Study of MK-8527 in Healthy Participants (MK-8527-021)
Sponsor: Merck Sharp & Dohme LLC
Summary
Researchers are studying a medicine called MK-8527 to learn how it behaves in the body of healthy adults. The goal of this study is to learn about the effect of MK-8527 when it is taken with food or with other medicines. Researchers also want to learn about the safety of MK-8527 and if people tolerate it. Tolerate means participants will receive treatment in the trial unless they need to stop it due to health problems.
Official title: An Open-label, Phase 1 Study to Individually Characterize the Food Effect, the Drug-Drug Interaction Effect of OAT Inhibition, and the Drug-Drug Interaction Effect of P-glycoprotein Inhibition on the Pharmacokinetics of MK-8527 in Healthy Adult Participants
Key Details
Gender
All
Age Range
18 Years - 55 Years
Study Type
INTERVENTIONAL
Enrollment
44
Start Date
2026-07-07
Completion Date
2026-10-09
Last Updated
2026-06-22
Healthy Volunteers
Yes
Conditions
Interventions
MK-8527
Oral tablet
Probenecid
Oral tablet
Itraconazole
Oral solution