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Controlled Hypotension and Renal Injury During Septoplasty
Sponsor: Fatih Sultan Mehmet Training and Research Hospital
Summary
This prospective randomized single-blind study investigated the effects of two different mean arterial pressure (MAP) targets during controlled hypotension on renal injury in patients undergoing septoplasty. Participants were randomized to a low MAP target group (50-57 mmHg) or a higher MAP target group (58-65 mmHg). Renal injury was assessed using plasma neutrophil gelatinase-associated lipocalin (NGAL) levels measured at baseline, 6 hours, and 24 hours postoperatively.
Official title: Effects of Two Different Mean Arterial Pressure Targets During Controlled Hypotension on Renal Injury Assessed by NGAL Levels in Patients Undergoing Septoplasty
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
110
Start Date
2019-05-01
Completion Date
2020-08-01
Last Updated
2026-06-23
Healthy Volunteers
No
Interventions
Controlled Hypotension (MAP 50-57 mmHg)
Controlled hypotension was maintained intraoperatively with a target MAP range of 50-57 mmHg according to the study protocol.
Controlled Hypotension (MAP 58-65 mmHg)
Controlled hypotension was maintained intraoperatively with a target MAP range of 58-65 mmHg according to the study protocol.
Locations (1)
FSMTRH
Istanbul, Ataşehir, Turkey (Türkiye)