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Effect of Platelet-Rich Plasma on Eardrum Healing and Hearing After Tympanoplasty in Adults
Sponsor: Ebubekir Toprak
Summary
This single-center controlled trial evaluated whether intraoperative application of autologous platelet-rich plasma (PRP)-impregnated absorbable gelatin sponge improves graft take rates and audiological outcomes in adults undergoing tympanoplasty for chronic otitis media with tympanic membrane perforation. Forty-eight patients were allocated by systematic alternation to a PRP group (PRP-impregnated Spongostan placed in the middle ear and lateral to the graft) or a control group (dry Spongostan). The primary outcome was graft integrity at two months; the secondary outcome was improvement in the air-bone gap.
Official title: Intraoperative Use of Platelet-Rich Plasma in Tympanoplasty: Effects on Graft Success and Audiological Outcomes - A Prospective Controlled Trial
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
48
Start Date
2023-04-01
Completion Date
2023-08-31
Last Updated
2026-06-24
Healthy Volunteers
Yes
Interventions
Autologous platelet-rich plasma (PRP)-impregnated Spongostan
PRP-impregnated absorbable gelatin sponge placed in the middle ear and lateral to the graft during tympanoplasty
Dry Spongostan (absorbable gelatin sponge)
Dry absorbable gelatin sponge placed in the same positions without PRP
Locations (1)
Sbü Sisli Hamidiye Etfal Eah
Istanbul, Sisli, Turkey (Türkiye)