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Novel Method for Removal of Orally Deposited Inhaled Fluticasone Propionate
Sponsor: University of Wisconsin, Madison
Summary
This study is to find out if an Extra Virgin Olive-Oil-based Water (EVOOW) mix, removes more Fluticasone Propionate (FP) from the mouth than Water alone. 2 strengths of the EVOOW mix will be tested, one with equal parts EVOO and Water (50/50) and one with 3 parts EVOO and 1 part Water (75/25). Removing more FP deposits may help decrease the risk for obstructive sleep apnea (OSA), candidiasis (thrush), and speech and swallow dysfunction. Participants will be on study for up to 3 weeks.
Official title: A Proof-of-Concept Study of a Novel Method for Removal of Residual Oropharyngeal Inhaled Corticosteroid Deposits in Asthma
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
20
Start Date
2026-06
Completion Date
2027-04
Last Updated
2026-06-24
Healthy Volunteers
Yes
Conditions
Interventions
Fluticasone Propionate
Participants will be administered 1 puff of 220 micrograms FP, via Metered Dose Inhaler, without inhaling into the lungs.
Water Mouthwash
Participants will rinse and gargle with 3 consecutive aliquots (20ml each) of either Water (W).
EVOOW Mouthwash
Participants will rinse and gargle with 3 consecutive aliquots (20 ml each) of an equal parts EVOO and Water mixture.
Locations (1)
University of Wisconsin
Madison, Wisconsin, United States