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Postoperative Cognitive Function After Different Anesthetic Techniques in Obese Patients
Sponsor: Gaziantep City Hospital
Summary
Obese patients are at increased risk of postoperative cognitive dysfunction (POCD). The effects of different anesthetic techniques on postoperative cognitive function remain controversial. This prospective randomized study aimed to compare the effects of low-flow sevoflurane anesthesia, normal-flow sevoflurane anesthesia, and total intravenous anesthesia (TIVA) on postoperative cognitive function and recovery characteristics in obese patients undergoing elective laparoscopic abdominal surgery. Cognitive function was assessed using the Mini-Mental State Examination (MMSE) before surgery, at postoperative 30 minutes, and on postoperative day 3.
Official title: Effects of Low-Flow Sevoflurane, Normal-Flow Sevoflurane, and Total Intravenous Anesthesia on Postoperative Cognitive Function in Obese Patients Undergoing Laparoscopic Abdominal Surgery
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
90
Start Date
2023-01-10
Completion Date
2023-06-20
Last Updated
2026-06-24
Healthy Volunteers
Yes
Interventions
Sevoflurane (Volatile Anesthetic)
Maintenance of general anesthesia with sevoflurane inhalation. Patients were assigned to either low-flow (1 L/min) or normal-flow (3 L/min) fresh gas flow anesthesia protocols.
propofol
Maintenance of total intravenous anesthesia using continuous propofol infusion under BIS monitoring.
Remifentanil
Continuous remifentanil infusion was administered during maintenance of anesthesia according to study protocol.
Locations (1)
Marmara University Faculty of Medicine Pendik Training and Research Hospital
Istanbul, Istanbul, Turkey (Türkiye)