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Topical Application of a Propolis-Based Solution for Extraction Socket Healing: A Split-Mouth Pilot Study
Sponsor: Saint-Joseph University
Summary
This pilot study evaluated whether a propolis-based topical solution improves soft-tissue healing after tooth extraction. Thirteen patients requiring extraction of two comparable teeth on opposite sides of the mouth were enrolled in a split-mouth design, in which one extraction site received the propolis solution while the other served as an internal control. The test site was treated with the propolis solution three times daily for seven days, while the control site received only saline rinses. Healing was tracked using 3D intraoral scans obtained before extraction and on days 7 and 14 afterward, allowing the percentage of socket closure to be measured objectively over time. Postoperative pain was also assessed using a standard visual pain scale on days 1, 3, and 7. The study aimed to determine whether this propolis-based formulation could serve as a natural, low-cost adjunct to standard post-extraction care to support faster tissue repair.
Official title: PROPOLIS-BASED SOLUTION APPLICATION IN EXTRACTION SOCKET HEALING: A 3D SPLIT-MOUTH CLINICAL PILOT STUDY
Key Details
Gender
All
Age Range
8 Years - Any
Study Type
INTERVENTIONAL
Enrollment
14
Start Date
2025-10-01
Completion Date
2026-04-01
Last Updated
2026-06-24
Healthy Volunteers
Yes
Conditions
Interventions
Propolis-based topical solution (52% propolis extract, clove oil [Eugenia caryophyllus], and white willow bark [Salix alba] extract)
Drug: Propolis-Based Solution "A topical solution (52% propolis extract, clove oil, and white willow bark extract) applied to the test extraction socket via brush applicator three times daily for seven days."
Saline rinse (control)
The contralateral extraction socket received saline mouthwash only, with no active therapeutic agent applied, following the same pre-application oral hygiene steps (tooth brushing and saline rinse) as the test site
Locations (1)
Saint Joseph University of Beirut
Beirut, Lebanon