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MMS, IFA, and MMS+IFA Supplementation in Pregnant Women: A Randomized Controlled Trial.
Sponsor: Sindh Institute of Child Health and Neonatology
Summary
This study aims to compare the effectiveness of Multiple Micronutrient Supplementation (MMS), Iron-Folic Acid (IFA) supplementation, and combined MMS+IFA supplementation among pregnant women. Maternal anemia and micronutrient deficiencies are common during pregnancy and can adversely affect both maternal and neonatal health outcomes. A total of 402 pregnant women with gestational age of 20 weeks or less will be randomly assigned to receive MMS, IFA, or combined MMS+IFA supplementation. Participants will be followed throughout pregnancy until delivery. Maternal hemoglobin levels, maternal compliance with supplementation, and neonatal outcomes including birth weight, preterm birth, APGAR scores, and congenital anomalies will be assessed. The findings of this study will provide evidence to guide antenatal nutrition policies and practices in Pakistan.
Official title: Comparative Effectiveness of Multiple Micronutrient Supplementation (MMS), Iron-Folic Acid (IFA), and Combined MMS+IFA on Maternal Hemoglobin Levels and Neonatal Outcomes Among Pregnant Women: An Open-Label Randomized Controlled Trial.
Key Details
Gender
FEMALE
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
402
Start Date
2026-06-25
Completion Date
2027-01-25
Last Updated
2026-06-24
Healthy Volunteers
Yes
Interventions
Multiple Micronutrient Supplementation (MMS)
WHO-standard multiple micronutrient supplement containing iron, folic acid, zinc, iodine, vitamins A, D, C, and B-complex vitamins administered daily during pregnancy
Iron-Folic Acid (IFA)
Iron 60 mg and folic acid 400 µg administered daily during pregnancy.