Clinical Research Directory

Inclusion Criteria: * For cases: Diagnosis of a rare bone and cartilage disorder confirmed by the Rare Disease Competence Center for Constitutional Bone Disorders (MOC) or Calcium and Phosphate Metabolism Disorders (CaP), genetically and/or clinically. * Ability to undergo a 3D intra-oral scan; * Ability of the participant to understand the information notice provided regarding the use of their medical data and 3D digital models for research purposes, and to express informed non-objection to participation in the research. * For controls: healthy adults recruited in the Dental Medicine Department. Exclusion Criteria: * History of major orthodontic/orthognathic treatment; * Craniofacial conditions unrelated to the studied diseases (e.g., cleft palate, non-target craniofacial syndromes); * Impossibility to obtain a 3D optical impression; * Refusal or inability of the participant to understand the information notice and/or to express informed non-objection to participation in the research.