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Pathological Mechanism Study of Aerobic Exercise Regulating Cold Stress-induced Hypertension Via the Thermosensitive Target-mediated Sympathetic Nerve Pathway
Sponsor: Wang Jingfeng
Summary
This study focuses on the specificity of thermosensitive targets in populations with hypertension in cold regions, identifies core targets through transcriptome sequencing and clinical validation, and clarifies the regulatory mechanism of moderate-intensity aerobic exercise through a prospective cohort study, providing scientific basis for precise prevention and treatment of hypertension in cold regions and personalized exercise intervention.
Key Details
Gender
All
Age Range
60 Years - 69 Years
Study Type
OBSERVATIONAL
Enrollment
200
Start Date
2024-10-04
Completion Date
2025-12-28
Last Updated
2026-06-24
Healthy Volunteers
No
Conditions
Interventions
Exercise exposure
Patients with essential hypertension in cold regions who met the inclusion criteria were prospectively recruited and divided into an exercise exposure group and a non-exercise control group based on their willingness to accept and adhere to the exercise protocol developed for this study, with a follow-up period of 16 weeks. At baseline and the end of follow-up, we measured the expression of core thermosensitive targets, blood pressure (BP), heart rate variability (HRV), as well as the levels of sympathetic neurotransmitters and indicators of the renin-angiotensin-aldosterone system (RAAS), and compared the changes in these indicators between the two groups.
Locations (1)
Harbin Sport University
Harbin, Heilongjiang, China