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NOT YET RECRUITING
NCT07667829
NA

Vasopressor Agents in Pulmonary Hypertension Crisis

Sponsor: China National Center for Cardiovascular Diseases

View on ClinicalTrials.gov

Summary

Comparison of the efficacy and safety of three vasoactive agents-dopamine, norepinephrine, and epinephrine-in the treatment of patients with pulmonary hypertension crisis: prospective, randomised controlled trial monitored by haemodynamic monitoring

Official title: Comparison of the Efficacy and Safety of Dopamine, Norepinephrine and Epinephrine in the Treatment of Pulmonary Hypertensive Crisis Under Hemodynamic Monitoring

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

75

Start Date

2026-06

Completion Date

2029-01-31

Last Updated

2026-06-25

Healthy Volunteers

No

Interventions

DRUG

Norepinephrine

The initial dose is 0.02 mg/kg/min of norepinephrine; each dose adjustment (increase or decrease) is 0.02 mg/kg/min of norepinephrine; the maximum dose of norepinephrine is 0.2 mg/kg/min.

DRUG

Dopamine

The initial dose is 2 μg/kg/min of dopamine; each dose adjustment (increase or decrease) is 2 μg/kg/min of dopamine; the maximum dose of dopamine is 20 μg/kg/min

DRUG

Epinephrine

The initial dose is 0.02 μg/kg/min of epinephrine; each adjustment (up or down) is 0.02 μg/kg/min of epinephrine; the maximum dose of epinephrine is 0.2 μg/kg/min

Locations (3)

Chinese Academy of Medical Sciences, Fuwai Hospital

Beijing, Beijing Municipality, China

Guangdong Provincial People's Hospital

Guangzhou, Guangdong, China

Zhongnan Hospital of Wuhan University

Wuhan, Wuhan, China