Clinical Research Directory

Inclusion Criteria: 1. Women with newly diagnosed breast cancer and ≥ 18 years old. 2. Naive to chemotherapy. 3. Left ventricular ejection fraction (LVEF) \> 55%. Exclusion Criteria: 1. Concurrent administration of any other cholesterol-lowering therapy. 2. Evidence of hepatic dysfunction (alanine aminotransferase level more than three times the upper limit of the normal range) 3. Evidence of renal dysfunction (creatinine level more than three times the upper limit of the normal range). 4. Predisposing factors for rhabdomyolysis, including hypothyroidism, reduced renal function, any muscle or liver disease. 5. Concurrent administration of potent CYP3A4-inhibitors. 6. Pregnancy or breast-feeding