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AMAZE 13: A Research Study Investigating How Well the Medicine Zenagamtide Helps People in Asia With Excess Body Weight Lose Weight
Sponsor: Novo Nordisk A/S
Summary
The purpose of this clinical study is to find out if zenagamtide is safe and effective for treating people who have excess body weight. There are 2 study treatments in this study taken as injections under the skin once a week. Participants will either get zenagamtide (the treatment being tested) or placebo (a treatment that has no active medicine in it). Which treatment participants get is decided by chance.
Official title: Efficacy and Safety of Zenagamtide s.c. Once-weekly in Asian Participants With Overweight or Obesity (AMAZE 13)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
400
Start Date
2027-01-07
Completion Date
2029-01-11
Last Updated
2026-07-21
Healthy Volunteers
No
Conditions
Interventions
Zenagamtide
Zenagamtide will be administered subcutaneously using PDS290 pre-filled pen-injectors to one of the body parts: thigh, abdomen or upper arm.
Placebo ( matched to Zenagamtide)
Placebo matched to Zenagamtide will be administered subcutaneously using PDS290 pre-filled pen-injectors to one of the body parts: thigh, abdomen or upper arm.
Locations (41)
Nirmal Hospital Pvt. Ltd.
Surat, Gujarat, India
SSG Hospital, Baroda
Vadodara, Gujarat, India
Karnataka Medical College and Research Institute
Hubbali, Karnataka, India
Government Medical College, Kozhikode
Kozhikode, Kerala, India
TOTALL Diabetes Hormone Institute
Indore, Madhya Pradesh, India
Shree Mahalaxmi DIATONE Institute
Kohlapur, Maharashtra, India
Excel Endocrine Centre
Kolhāpur, Maharashtra, India
BSES MG hospital
Mumbai, Maharashtra, India
All India Institute of Medical Sciences (AIIMS), Nagpur
Nagpur, Maharashtra, India
Shalini Tai Meghe Hospital and Research Center
Nagpur, Maharashtra, India
Vijan Hospital & Research Centre
Nashik, Maharashtra, India
Grant Medical Foundation Ruby Hall Clinic
Pune, Maharashtra, India
Chellaram Diabetes Institute
Pune, Maharashtra, India
Maulana Azad Medical College
Delhi, New Delhi, India
Madras Diabetes Research Foundation
Chennai, Tamil Nadu, India
Christian Medical College Hospital, Vellore
Vellore, Tamil Nadu, India
Diabetes Research Center, Hyderabad
Hyderabad, Telangana, India
Osmania General Hospital
Hyderabad, Telangana, India
All India Institute of Medical Science (AIIMS), Guwahati
Assam, India
SMS Hospital
Jaipur, India
GMERS Medical college and hospital
Vadodara, India
OCROM Clinic_Internal medicine
Suita-shi, Osaka, Japan
Kindai University Hospital_Department of Endocrinology, Metabolism and Diabetes
Sakai-shi, Osaka, Japan
Medical Corporation Shinanokai Shinanozaka Clinic_Internal Medicine
Shinjuku-ku, Tokyo, Japan
Tokyo-Eki Center-building Clinic_Internal Medicine
Tokyo, Japan
Fukuwa Clinic_Internal Medicine
Tokyo, Japan
ToCROM Clinic_Internal Medicine
Tokyo, Japan
Hospital Canselor Tuanku Muhriz UKM
Cheras, Kuala Lumpur, Malaysia
University Malaya Medical Centre
Lembah Pantai, Kuala Lumpur, Malaysia
Hospital Miri
Miri, Sarawak, Malaysia
Hospital Melaka
Malacca, Malaysia
Hospital Putrajaya
Putrajaya, Malaysia
Seoul National University Bundang Hospital_Endocrinology
Seoungnam-si, Gyeonggi-do, South Korea
Ajou University Hospital_Family Medicine
Suwon, Gyeonggi-do, South Korea
Pusan National University Yangsan Hospital_Family Medicine
Yangsan, Gyeongsangnam-do, South Korea
Kyungpook National University Hospital_Family Medicine
Daegu, South Korea
Konkuk University Medical Center_Endocrinology
Seoul, South Korea
Ramathibodi Hospital
Bangkok, Thailand
Siriraj Institute of Clinical Research
Bangkok, Thailand
Thammasat Hospital_CRC
Pathum Thani, Thailand
Songklanagarind Hospital
Songkhla, Thailand