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A Research Study Investigating How Well the Medicine Zenagamtide Helps People With Excess Body Weight Lose Weight Compared to Semaglutide
Sponsor: Novo Nordisk A/S
Summary
The purpose of this study is to find out if zenagamtide is safe and effective for treating participants who have excess body weight compared to treatment with semaglutide.
Official title: Efficacy and Safety of Zenagamtide s.c. Once-weekly Compared to Semaglutide s.c. Once-weekly in Participants With Obesity (AMAZE 7)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
650
Start Date
2026-09-22
Completion Date
2028-10-10
Last Updated
2026-06-25
Healthy Volunteers
No
Conditions
Interventions
Zenagamtide
Zenagamtide will be administered subcutaneously using pre-filled pen-injectors to one of the body parts: thigh, abdomen or upper arm.
Semaglutide
Semaglutide will be administered subcutaneously using pre-filled pen-injectors to one of the body parts: thigh, abdomen or upper arm.
Placebo (matched to semaglutide)
Placebo matched to semaglutide will be administered subcutaneously using pre-filled pen-injectors to one of the body parts: thigh, abdomen or upper arm.
Placebo (matched to zenagamtide)
Placebo matched to zenagamtide will be administered subcutaneously using pre-filled pen-injectors to one of the body parts: thigh, abdomen or upper arm.
Locations (46)
First Valley Medical Group
Lancaster, California, United States
Desert Oasis Healthcare
Palm Springs, California, United States
Western University of Health Sciences
Pomona, California, United States
Artemis Insitute for Clin Res
San Diego, California, United States
Med Home Development Grp
Washington D.C., District of Columbia, United States
Encore Medical Research LLC
Hollywood, Florida, United States
NextPhase Research
Hollywood, Florida, United States
Jacksonville Ctr Clin Res
Jacksonville, Florida, United States
PharmaDev Clinical Research Institute LLC
Miami, Florida, United States
South Broward Research LLC
Miramar, Florida, United States
Essence MD Research
Naples, Florida, United States
Florida Inst For Clin Res LLC
Orlando, Florida, United States
Oviedo Medical Research, LLC
Oviedo, Florida, United States
Palm Beach Research Center
West Palm Beach, Florida, United States
Encore Medical Research of Weston
Weston, Florida, United States
Conquest Research
Atlanta, Georgia, United States
Eastside Bariatric and Gen Surg
Snellville, Georgia, United States
Chicago Research Center, Inc
Chicago, Illinois, United States
Endeavor Health
Skokie, Illinois, United States
Midwest Inst For Clin Res
Indianapolis, Indiana, United States
Southern Clin Research
Zachary, Louisiana, United States
Amicis Centers of Clinical Research
St Louis, Missouri, United States
Ichor Research
Syracuse, New York, United States
Southgate Medical Group, LLP
West Seneca, New York, United States
University of North Carolina
Chapel Hill, North Carolina, United States
PharmQuest Life Sciences LLC
Greensboro, North Carolina, United States
Piedmont Healthcare/Research
Statesville, North Carolina, United States
Lillestol Research LLC
Fargo, North Dakota, United States
Geisinger Clinic
Danville, Pennsylvania, United States
Medical University Of South Carolina
Charleston, South Carolina, United States
Hillcrest Clinical Research
Simpsonville, South Carolina, United States
Spartanburg Medical Research
Spartanburg, South Carolina, United States
Amarillo Med Spec LLP
Amarillo, Texas, United States
Texas Diabetes & Endocrinology
Austin, Texas, United States
Pinnacle Clinical Research
Brownsville, Texas, United States
Osvaldo A. Brusco MD
Corpus Christi, Texas, United States
UT Southwestern Med Center
Dallas, Texas, United States
Epic Medical Research
DeSoto, Texas, United States
Houston Research Institute
Houston, Texas, United States
The Endocrine Center
Houston, Texas, United States
Sleep Therapy Research Center
San Antonio, Texas, United States
Olympus Clinical Research
Sugar Land, Texas, United States
National Clin Res Inc.
Richmond, Virginia, United States
Gastroent Consult of SW VA
Roanoke, Virginia, United States
Rainier Clin Res Ctr Inc
Renton, Washington, United States
Seattle Clinical Research Center
Seattle, Washington, United States