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Preoperative Ankle-Brachial Index and Renal Adverse Events After Acute Type A Aortic Dissection Surgery
Sponsor: Nanjing First Hospital, Nanjing Medical University
Summary
This single-centre retrospective observational cohort study evaluated the association between preoperative cuff-derived ankle-brachial index (ABI) and postoperative acute kidney injury (AKI) in adults undergoing emergency repair of acute type A aortic dissection. Existing clinical data from patients treated at Nanjing First Hospital, Nanjing Medical University, between January 2019 and February 2024 were used. High ABI was defined as \>1.40, and the reference ABI range was defined as \>0.90 and ≤1.40. The primary outcome was creatinine-defined AKI within 7 postoperative days. Exploratory analyses examined whether the association between cumulative intraoperative mean arterial pressure exposure and AKI differed according to ABI phenotype. No intervention or treatment allocation was assigned by the study protocol.
Official title: Association Between Preoperative Ankle-Brachial Index and Postoperative Renal Adverse Events in Patients With Acute Stanford Type A Aortic Dissection: A Single-Center Retrospective Cohort Study
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
516
Start Date
2019-01-01
Completion Date
2024-02-29
Last Updated
2026-09-21
Healthy Volunteers
No
Interventions
Preoperative Ankle-Brachial Index
Preoperative ABI was derived from routine four-limb oscillometric cuff pressure measurements. Each ankle systolic pressure was divided by the higher brachial systolic pressure, and the higher of the two side-specific ABI values was used for patient classification. High ABI was defined as \>1.40 and reference ABI as \>0.90 and ≤1.40. No intervention was assigned by the study protocol.
Locations (1)
Nanjing First Hospital, Nanjing Medical University
Nanjing, Jiangsu, China