Clinical Research Directory

Brain Radiotherapy Imaging for High-grade Glioma Using Hypoxia Targeting Through Oxygen-Enhanced Response

Sponsor: The Leeds Teaching Hospitals NHS Trust

Summary

High-grade gliomas (HGGs) are the most common type of brain cancer in adults. Life expectancy for patients with HGGs is low. Radiotherapy aims to cure the tumour, but this is hard because HGGs are resistant to treatment. Among the possible causes of resistance may be tumour cells with low-oxygen levels (hypoxia). We know this makes tumours less sensitive to radiotherapy. Using a special imaging technique called oxygen-enhanced MRI (OE-MRI) we can try to identify areas of the tumour with hypoxia. We could then give those areas a higher dose of radiotherapy. This might improve tumour control. This study aims to see if OE-MRI can find low-oxygen areas in HGGs. It will also check if we can simulate higher doses of radiotherapy in these regions. Project summary: 1. Set up the OE-MRI process at Leeds Cancer Centre (LCC). OE-MRI settings will be tested on healthy volunteers to ensure the images are as good as possible. 2. Patient Imaging. Patients with HGG will be recruited to take part. OE-MRI will be used to image patients during their treatment and track low-oxygen areas before treatment, halfway through treatment and 3 months after treatment has finished. 3. Dose Escalation Assessment. Computer programs will be used to design radiotherapy treatments to test if higher radiation doses to the tumour's low-oxygen areas can better control the cancer. This will help understand if this targeted approach has potential benefits. This is modelling and will not alter routine clinical patient management.

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