Clinical Research Directory
Browse clinical research sites, groups, and studies.
Exocrine-Endocrine Pancreatic Crosstalk: Precision Pathways to Reframe Diabetes Pathophysiology
Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Summary
The EXPAND study is a prospective observational study designed to investigate the biological mechanisms underlying the heterogeneity of type 2 diabetes and related metabolic disorders. The study will enroll adults with and without pancreatic disease, including patients undergoing pancreatic surgery, individuals with chronic pancreatitis, subjects at high risk of type 2 diabetes, and patients with newly diagnosed type 2 diabetes. Clinical, metabolic, imaging, genetic, microbiome, and molecular data will be integrated to identify distinct metabolic endotypes and to investigate the interactions between the exocrine pancreas, endocrine pancreas, and adipose tissue. The ultimate goal is to improve the understanding of diabetes pathophysiology and support the development of precision medicine approaches.
Key Details
Gender
All
Age Range
20 Years - 78 Years
Study Type
OBSERVATIONAL
Enrollment
440
Start Date
2026-09
Completion Date
2031-09
Last Updated
2026-06-26
Healthy Volunteers
No