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NOT YET RECRUITING
NCT07671079
NA

Closed-loop tES-non-invasive Stimulation

Sponsor: University of Nottingham

View on ClinicalTrials.gov

Summary

The goal of this study is to establish if non-invasive closed-loop neuromodulation is an effective approach to enhance cognitive function in healthy 18-40 years old volunteers. The main questions it aims to answer are: * Can closed-loop stimulation increase stimulation effectiveness? * Can closed-loop focused ultrasound specifically engage with excitatory or inhibitory neural populations in the target structure as measured through MRS? * Can observed stimulation outcomes for FUS be predicted through connectome analysis and computational models of indirect changes? Researchers will compare different closed-loop options to their open-loop counterpart to see if closed-loop approaches can increase efficacy and reduce the variability of the stimulation compared to open-loop approaches. Participants will: * Answer some questionnaires at the start of the study and after each intervention session. * Undertake a MRI scanning session. * Undertake one open-loop FUS session. * Undertake one tES session. * Undertake one closed-loop FUS sessions involving tES and FUS, followed by a MRI scanning * Undertake one sham FUS session * Attend one visit in person to assess eligibility through questionnaires and one cognitive task

Official title: Closed-loop Non-invasive Stimulation for Improving Brain and Mental Health in Healthy Individuals

Key Details

Gender

All

Age Range

18 Years - 40 Years

Study Type

INTERVENTIONAL

Enrollment

30

Start Date

2026-07

Completion Date

2027-12

Last Updated

2026-06-26

Healthy Volunteers

Yes

Interventions

OTHER

Transcranial low intensity focused ultrasound (FUS)

Low intensity focused ultrasound stimulation (FUS) with 500kHz transducer for following either the continuous theta burst or intermittent theta burst protocol using the NeuroFus PRO system

OTHER

transcranial electrical stimulation

Transcranial electrical stimulation (by means of transcranial alternating current stimulation (tACS) or non-invasive temporal interference (TI) electrical stimulation) using the DS5 isolated bipolar constant current stimulator together connected to a wave generator and with two electrodes for tACS (TI implementation will be carried out with two DS5 systems, separate wave generators and four electrodes).

PROCEDURE

Magnetic Resonance Imaging

We obtain baseline functional, metabolic and structural information through MRI and MRS scanning

Locations (1)

University of Nottingham

Nottingham, United Kingdom