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Angiotensin II for Post Cardiac Surgery Vasoplegia (ANGII_V)
Sponsor: Methodist Healthcare System of San Antonio
Summary
The goal of this study is to conduct a prospective trial implementing a modified version of the Emory Protocol for administering ANG II to patients with post cardiac bypass vasoplegia. The main questions we aim to answer are: 1.) does administration of improve mortality, 2.) does the administration of Ang II using the modified protocol shorten the time needed to reach optimal MAP, 3.) does the administration of Ang II using the modified protocol shorten length of stay in the ICU and hospital? Researchers will compare outcomes from the interventional group to historical controls who did not receive Ang II using the modified protocol.
Key Details
Gender
All
Age Range
18 Years - 94 Years
Study Type
INTERVENTIONAL
Enrollment
329
Start Date
2026-07
Completion Date
2030-08
Last Updated
2026-06-26
Healthy Volunteers
No
Interventions
Angiotensin II (Giapreza®)
Patients who have post cardiopulmonary bypass vasoplegia who are already on vasopressin 0.04 units/min, norepinephrine 0.1 mcg/kg/min will have Ang II initiated at 10 to 20 ng/kg/min and titrated by 10 ng/kg/min every 5 minutes to a maximum dose of 80 ng/kg/min.