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Effect of Ozone Therapy on Remineralization of Initial Caries Lesions in Children
Sponsor: Neslihan Atmaca
Summary
Initial caries lesions can be managed using non-invasive treatment approaches that promote remineralization and prevent lesion progression. Ozone therapy has been suggested as an adjunctive treatment because of its antimicrobial properties and its potential to enhance remineralization. This randomized controlled clinical trial aims to evaluate the effect of ozone therapy on the remineralization of initial caries lesions in children. Participants will be randomly assigned to receive either ozone therapy followed by application of a remineralizing gel or application of the remineralizing gel alone. Changes in lesion status will be assessed over time using clinical and optical evaluation methods. The results of this study may contribute to the development of evidence-based minimally invasive approaches for the management of early caries lesions in pediatric patients.
Official title: Effect of Ozone Therapy on the Remineralization of Initial Caries Lesions in Children: A Randomized Controlled Clinical Trial
Key Details
Gender
All
Age Range
6 Years - 14 Years
Study Type
INTERVENTIONAL
Enrollment
80
Start Date
2026-06-01
Completion Date
2027-04-20
Last Updated
2026-06-26
Healthy Volunteers
No
Conditions
Interventions
Ozone Therapy
Ozone therapy administered using the Ozonytron device for the treatment of initial caries lesions.
other
ROCS Medical Minerals gel applied according to the manufacturer's instructions for remineralization of initial caries lesions.
Locations (1)
Marmara Universty School of Dentistry
Istanbul, Maltepe, Turkey (Türkiye)