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Magnetic Resonance-Guided Stereotactic Body Radiation Therapy for the Treatment of Metastatic Solid Tumors, ONE SHOT Trial
Sponsor: Jonsson Comprehensive Cancer Center
Summary
This clinical trial studies the side effects of magnetic resonance (MR)-guided stereotactic body radiation therapy (SBRT) and to see how well it works in treating patients with solid tumors that have spread from where they first started (primary site) to other places in the body (metastatic). SBRT is a type of external radiation therapy that uses special equipment to position a patient and precisely deliver radiation to tumors in the body. The total dose of radiation is divided into smaller doses given over 1-5 days. This type of radiation therapy helps spare normal tissue. During MR-guided SBRT, MR imaging is used to define and localize the area to be treated and provide more accurate delivery. This allows the treatment to be given over one day. MR-guided SBRT may be safe, tolerable, and/or effective in treating patients with metastatic solid tumors. Tumors in the central nervous system will not be treated on this study.
Official title: ONE SHOT: Single-Fraction Adaptive MR-Guided Radiation Therapy for Metastatic Solid Tumors
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
25
Start Date
2026-07-01
Completion Date
2038-07-01
Last Updated
2026-06-26
Healthy Volunteers
No
Conditions
Interventions
Computed Tomography
Undergo CT and/or PET/CT
Magnetic Resonance Imaging
Undergo MRI
MRI-guided Stereotactic Body Radiation Therapy
Undergo MR-guided SBRT
Positron Emission Tomography
Undergo PET/CT
Questionnaire Administration
Ancillary studies
Locations (1)
UCLA / Jonsson Comprehensive Cancer Center
Los Angeles, California, United States