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NOT YET RECRUITING
NCT07671768
NA

Magnetic Resonance-Guided Stereotactic Body Radiation Therapy for the Treatment of Metastatic Solid Tumors, ONE SHOT Trial

Sponsor: Jonsson Comprehensive Cancer Center

View on ClinicalTrials.gov

Summary

This clinical trial studies the side effects of magnetic resonance (MR)-guided stereotactic body radiation therapy (SBRT) and to see how well it works in treating patients with solid tumors that have spread from where they first started (primary site) to other places in the body (metastatic). SBRT is a type of external radiation therapy that uses special equipment to position a patient and precisely deliver radiation to tumors in the body. The total dose of radiation is divided into smaller doses given over 1-5 days. This type of radiation therapy helps spare normal tissue. During MR-guided SBRT, MR imaging is used to define and localize the area to be treated and provide more accurate delivery. This allows the treatment to be given over one day. MR-guided SBRT may be safe, tolerable, and/or effective in treating patients with metastatic solid tumors. Tumors in the central nervous system will not be treated on this study.

Official title: ONE SHOT: Single-Fraction Adaptive MR-Guided Radiation Therapy for Metastatic Solid Tumors

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

25

Start Date

2026-07-01

Completion Date

2038-07-01

Last Updated

2026-06-26

Healthy Volunteers

No

Interventions

PROCEDURE

Computed Tomography

Undergo CT and/or PET/CT

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

RADIATION

MRI-guided Stereotactic Body Radiation Therapy

Undergo MR-guided SBRT

PROCEDURE

Positron Emission Tomography

Undergo PET/CT

OTHER

Questionnaire Administration

Ancillary studies

Locations (1)

UCLA / Jonsson Comprehensive Cancer Center

Los Angeles, California, United States