Clinical Research Directory

Inclusion Criteria: * Severe symptomatic degenerative mitral regurgitation (grade 3+) * High surgical risk for open-heart mitral valve repair or replacement * Suitable anatomy for transcatheter chordal repair as determined by the treating physician * Ability to undergo required echocardiographic and fluoroscopic imaging * Ability to provide informed consent Exclusion Criteria: * Active endocarditis or systemic infection * Severe left ventricular dysfunction (LVEF \<30%) * Significant non-mitral valvular disease requiring intervention * Severe mitral annular calcification (MAC) * Presence of intracardiac or femoral venous thrombus or thrombus in the inferior vena cava * Cerebrovascular events (TIA, CVA) or thromboembolic events within the previous 6 months. * Renal insufficiency * Inability to undergo required imaging or access * Inability to tolerate standard anticoagulation or antithrombotic regimen * Rheumatic mitral valve disease * Co-morbid condition limiting life expectancy or study completion * Pregnancy * Participation in another clinical trial * Previous device treatment for MR.