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Omega-3 Plus Low-Dose Aspirin in Smokers With Stage III Periodontitis
Sponsor: Al-Azhar University
Summary
This randomized double-blind placebo-controlled clinical trial aims to evaluate the clinical and biochemical effects of omega-3 fatty acids combined with low-dose aspirin as an adjunct to scaling and root planing (SRP) in smoker patients with Stage III periodontitis. The study compares test and control groups regarding periodontal clinical parameters and gingival crevicular fluid interleukin-1 beta (IL-1β) levels Or other inflammatory markers that will be determined later at baseline, 3 months, and 6 months following treatment
Official title: Clinical and Biochemical Evaluation of the Effect of Omega-3 Fatty Acids Plus Low-Dose Aspirin as an Adjunct to Non-Surgical Periodontal Therapy in Smoker Patients With Stage III Periodontitis: A Randomized Double-Blind Placebo-Controlled Clinical Trial
Key Details
Gender
All
Age Range
30 Years - 50 Years
Study Type
INTERVENTIONAL
Enrollment
40
Start Date
2025-01-15
Completion Date
2026-10-30
Last Updated
2026-06-29
Healthy Volunteers
No
Interventions
Omega-3 Fatty Acids (EPA plus DHA) plus low dose aspirin
Matching placebo capsules administered orally once daily for 6 months following scaling and root planing.
Locations (1)
Faculty of Dental Medicine for Girls, Al-Azhar University
Cairo, Cairo Governorate, Egypt