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Personalized Ventilator Settings for Patients on ECMO
Sponsor: University of California, San Diego
Summary
While mechanical ventilation can be used to sustain life in those with lung injury, it, can further worsen lung injury or prevent lung healing resulting in high morbidity and mortality as seen in Acute Respiratory Distress Syndrome (ARDS). Using extracorporeal membrane oxygenation (ECMO), the highest level of life support also known as the heart-lung machine, investigators may minimize injury from mechanical ventilation to allow the lungs to heal; however, the optimal ventilator strategies while on ECMO are unknown. This study will evaluate personalized ventilator strategy compared to standard of care ventilation.
Official title: Personalized Ventilator Settings for Patients on ECMO (PEEPECMO)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
62
Start Date
2026-09-01
Completion Date
2031-06-30
Last Updated
2026-06-29
Healthy Volunteers
No
Conditions
Interventions
Personalized Positive End-Expiratory Pressure (PEEP)
The personalized Positive End-Expiratory Pressure (PEEP) will be determined by esophageal manometry or electrical impedance tomography (EIT)
Locations (1)
UC San Diego Health Jacobs Medical Center
La Jolla, California, United States