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A Study to Assess the Absolute Bioavailability and How Adimanebart SC Moves Through the Body in Healthy Adult Participants
Sponsor: argenx
Summary
This study aims to find out how much adimanebart gets into the blood circulation of healthy adults. Researchers will measure the amount of adimanebart in blood over time to learn how it moves through the body. The drug's safety will also be assessed. The participants will be assigned to one of 3 parts of the study: part 1 investigates the absolute bioavailability; part 2 investigates the effect of different body weights on adimanebart in blood after subcutaneous (SC) dosing; part 3 investigates formulation adaptations. Participants will be in the study for approximately up to 24 weeks.
Official title: A Phase 1, Open-Label, Randomized, Single Dose, Parallel-Group Study to Assess the Absolute Bioavailability and Evaluate the Effect of Body Weight on the Pharmacokinetics of Adimanebart SC in Healthy Adult Participants
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
52
Start Date
2026-06-12
Completion Date
2026-12
Last Updated
2026-06-29
Healthy Volunteers
Yes
Conditions
Interventions
Adimanebart IV
Intravenous infusion of adimanebart IV
Adimanebart SC - formulation A
Subcutaneous administration of Adminanebart SC
Adimanebart SC - formulation B
Subcutaneous administration of Adminanebart SC
Adimanebart SC - formulation C
Subcutaneous administration of Adminanebart SC
Locations (1)
Altasciences
Montreal, Canada