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RECRUITING
NCT07673601
PHASE1

A Study to Assess the Absolute Bioavailability and How Adimanebart SC Moves Through the Body in Healthy Adult Participants

Sponsor: argenx

View on ClinicalTrials.gov

Summary

This study aims to find out how much adimanebart gets into the blood circulation of healthy adults. Researchers will measure the amount of adimanebart in blood over time to learn how it moves through the body. The drug's safety will also be assessed. The participants will be assigned to one of 3 parts of the study: part 1 investigates the absolute bioavailability; part 2 investigates the effect of different body weights on adimanebart in blood after subcutaneous (SC) dosing; part 3 investigates formulation adaptations. Participants will be in the study for approximately up to 24 weeks.

Official title: A Phase 1, Open-Label, Randomized, Single Dose, Parallel-Group Study to Assess the Absolute Bioavailability and Evaluate the Effect of Body Weight on the Pharmacokinetics of Adimanebart SC in Healthy Adult Participants

Key Details

Gender

All

Age Range

18 Years - 65 Years

Study Type

INTERVENTIONAL

Enrollment

52

Start Date

2026-06-12

Completion Date

2026-12

Last Updated

2026-06-29

Healthy Volunteers

Yes

Interventions

BIOLOGICAL

Adimanebart IV

Intravenous infusion of adimanebart IV

BIOLOGICAL

Adimanebart SC - formulation A

Subcutaneous administration of Adminanebart SC

BIOLOGICAL

Adimanebart SC - formulation B

Subcutaneous administration of Adminanebart SC

BIOLOGICAL

Adimanebart SC - formulation C

Subcutaneous administration of Adminanebart SC

Locations (1)

Altasciences

Montreal, Canada