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Brain Wave Informed Non-invasive Brain Stimulation: Improving Neural Networks of Working Memory in Dementia: a Proof-of-concept Study
Sponsor: McMaster University
Summary
Working memory helps us hold information for a short time so one can think and make decisions. It keeps thoughts on track. As one gets older, working memory gets weaker. In people with dementia, it gets much worse, making it harder to talk with others, follow directions, or remember things like shopping lists. This may happen because brain waves that support working memory fall out of sync. Researchers can see these brain waves using a test called EEG. In this study, the investigators will try to get these brain waves back in sync using a safe, non-invasive form of brain stimulation called transcranial magnetic stimulation (TMS), and will time it to each person's brain waves to make it more effective. The goal is to improve working memory in people with dementia. If successful, dementia patients may be able to be more independent taking pressure off their families.
Key Details
Gender
All
Age Range
55 Years - Any
Study Type
INTERVENTIONAL
Enrollment
30
Start Date
2026-06-01
Completion Date
2028-08-01
Last Updated
2026-06-29
Healthy Volunteers
No
Conditions
Interventions
EEG-triggered TMS
This intervention involves delivering transcranial magnetic stimulation (TMS) to the dorsolateral prefrontal cortex (dlPFC) during working memory maintence timed to a specific electroencephalography (EEG) phase from the temporal cortex. The intervention is attempting to facilitate improved communication between the dlPFC and temporal cortex to improve working memory in people living with dementia.
Locations (1)
Ivor Wynne Center
Hamilton, Ontario, Canada