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Outlining Biological Effects of Subthalamic Deep Brain Stimulation in Parkinson's Disease Patients.
Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Summary
The aim of the study is to characterize the neuroinflammatory effects of subthalamic deep brain stimulation in patients with Parkinson's disease, by analyzing changes in blood neuroinflammatory and neurodegenerative biomarkers before and after surgery (at 6 and 12 months, respectively), and comparing the changes in blood biomarkers levels with a control group of patients with advanced PD on best medical treatment.
Official title: Outlining Biological Effects of Subthalamic Deep Brain Stimulation in Parkinson's Disease Patients: Insights Into Fluid Biomarkers of Neuroinflammation and Correlations With Clinical Outcomes
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
OBSERVATIONAL
Enrollment
90
Start Date
2026-09-01
Completion Date
2028-02-29
Last Updated
2026-06-29
Healthy Volunteers
Not specified
Conditions
Interventions
Deep brain stimulation surgery
The patients of DBS group will undergo surgical implantation of a system of deep brain stimulation in the subthalamic nucleus bilaterally, according to clinical practice.