Clinical Research Directory

Inclusion Criteria: \- Each participant must meet all the following criteria to be enrolled in this study: 1. Male or female aged 18-40 years 2. HIV-positive 3. Virologically suppressed, defined as HIV RNA \<50 copies/mL 4. No known history of HIV treatment failure 5. On a stable first-line ART regimen for ≥ 12 months and TDF/3TC/DTG for ≥ 6 months prior to enrolment 6. BMI \< 35 kg/m² and weight \>35kg 7. Women of childbearing potential must have a negative pregnancy test at screening, must use acceptable contraception throughout the study, and must not be planning pregnancy during the study period 8. Willing and able to undergo overnight PSG as required by the protocol 9. Clinically stable with no uncontrolled comorbidities as assessed by the investigator 10. Able and willing to provide written informed consent Exclusion Criteria: \- Participants meeting any of the following criteria will be excluded from the study: 1. Planned or recent (30 days before enrolment) changes to chronic medication, or anticipated medication changes during the study period, if applicable 2. Known contraindication to Delstrigo (hepatic impairment, hypersensitivity, strong CYP450 inducers) 3. Previous NNRTI use or prior documented NNRTI mutations 4. Clinical suspicion of TB 5. Insufficient total sleep time on screening polysomnography to permit reliable interpretation of sleep parameters or to confirm or exclude a sleep disorder. 6. Evidence of a clinically significant sleep disorder at screening, based on history, the site-specific Sleep Disorders Screening Tool (SDST) and/or polysomnography, including but not limited to: 1. Suspected or confirmed OSA 2. Suspected or known insomnia 3. Suspected restless legs syndrome (RLS), or periodic limb movements on PSG 4. Narcolepsy 7. Use of medications known to significantly alter sleep, including (but not limited to): 1. Benzodiazepines 2. Non-benzodiazepine sedative-hypnotics 3. Antipsychotics or mood stabilisers 4. Antidepressants with significant sedating effects 5. Isoniazid 6. Anticonvulsants e.g. carbamazepine, phenytoin, phenobarbital 8. Current alcohol use disorder or substance use (including illicit substances) that may interfere with sleep or study assessments, as determined by the investigator. 9. Pregnant, breastfeeding, or planning to become pregnant during the study period, or currently nursing or caring for an infant younger than 6 months at home 10. Active psychiatric illness that might interfere with study procedures or overnight assessments, as assessed by the investigator 11. Regular shift work defined as working more than three nights or rotating shifts per month at baseline or during the study, or having transitioned from night-shift to day-shift duties within the past month 12. Known or suspected significant neurological conditions that may interfere with sleep (e.g., epilepsy, neurodegenerative disorders, or a history of moderate-to-severe traumatic brain injury). 13. Current participation in another clinical trial, observational or interventional