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RECRUITING
NCT07674264
NA

Cross-System Effects of Acute Intermittent Hypercapnia-Based Interventions in PD

Sponsor: University of Florida

View on ClinicalTrials.gov

Summary

Parkinsonism impairs upper airway and axial motor control, leading to disordered breathing, reduced speech volume, and ineffective cough. Symptoms are poorly addressed by current therapies. This randomized pilot trial tests whether a single session of acute intermittent hypercapnic hypoxia (AIHH) or hypercapnic normoxia (AIHN) improves upper airway and axial motor function in Parkinsonism, and explores biomarker correlates of intervention responsiveness.

Official title: A Pilot Study of Acute Intermittent Hypercapnia-Based Interventions on Upper Airway and Axial Motor Function in Parkinson's Disease

Key Details

Gender

All

Age Range

40 Years - 75 Years

Study Type

INTERVENTIONAL

Enrollment

32

Start Date

2026-06-20

Completion Date

2028-12-31

Last Updated

2026-06-29

Healthy Volunteers

No

Interventions

OTHER

Acute intermittent hypercapnic hypoxia (AIHH)

Participants randomized to Group 1 will breathe brief bouts of AIHH, involving 15, 1.5-min exposures to 9-10% O2 and 4-5% CO2, alternated with 1 minute of 21% O2 (room air).

OTHER

Acute intermittent hypercapnic normoxia (AIHN)

Participants randomized to Group 2 will breathe brief bouts of AIHN, involving 15, 1.5-min exposures to 21% O2 and 4-5% CO2, alternated with 1 minute of 21% O2 (room air).

Locations (2)

University of Florida

Gainesville, Florida, United States

Norman Fixel Institute for Neurological Diseases

Gainesville, Florida, United States