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Cross-System Effects of Acute Intermittent Hypercapnia-Based Interventions in PD
Sponsor: University of Florida
Summary
Parkinsonism impairs upper airway and axial motor control, leading to disordered breathing, reduced speech volume, and ineffective cough. Symptoms are poorly addressed by current therapies. This randomized pilot trial tests whether a single session of acute intermittent hypercapnic hypoxia (AIHH) or hypercapnic normoxia (AIHN) improves upper airway and axial motor function in Parkinsonism, and explores biomarker correlates of intervention responsiveness.
Official title: A Pilot Study of Acute Intermittent Hypercapnia-Based Interventions on Upper Airway and Axial Motor Function in Parkinson's Disease
Key Details
Gender
All
Age Range
40 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
32
Start Date
2026-06-20
Completion Date
2028-12-31
Last Updated
2026-06-29
Healthy Volunteers
No
Conditions
Interventions
Acute intermittent hypercapnic hypoxia (AIHH)
Participants randomized to Group 1 will breathe brief bouts of AIHH, involving 15, 1.5-min exposures to 9-10% O2 and 4-5% CO2, alternated with 1 minute of 21% O2 (room air).
Acute intermittent hypercapnic normoxia (AIHN)
Participants randomized to Group 2 will breathe brief bouts of AIHN, involving 15, 1.5-min exposures to 21% O2 and 4-5% CO2, alternated with 1 minute of 21% O2 (room air).
Locations (2)
University of Florida
Gainesville, Florida, United States
Norman Fixel Institute for Neurological Diseases
Gainesville, Florida, United States